葡萄糖调节蛋白 78 在泌尿系肿瘤中的研究进展-泌尿外科杂志(电子版)

内质网（endoplasmic reticulum，ER）是细胞中蛋白质、类固醇、脂类的合成场所，对于细胞的活动和生存是不可缺少的。多种因素使 ER 稳态被打破，发生错误折叠和未折叠蛋白反应（unfolded protein response，UPR），在 ER 腔内聚集以及引起钙离子平衡紊乱，称为内质网应激（endoplasmic reticulum stress，ERS）。葡萄糖调节蛋白 78 （glucose regulated protein 78，GRP78）作为一种分子伴侣，在蛋白质的折叠、转运过程和 ERS 反应中发挥重要作用。近年发现，GRP78在泌尿系肿瘤中过表达，可能与泌尿系肿瘤，如前列腺癌、肾细胞癌、膀胱癌的恶性生物学行为，如增殖、凋亡、侵袭等密切相关[1-2] ，本文对 GRP78表达在泌尿系肿瘤的研究进展作一综述。

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赵越,付伟金. 葡萄糖调节蛋白78在泌尿系肿瘤中的研究进展[J]. 泌尿外科杂志（电子版）,2021,13(3):81-84. DOI:10.3969/j.issn.1674-7410.2021.03.020.

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内质网（endoplasmic reticulum，ER）是细胞中蛋白质、类固醇、脂类的合成场所，对于细胞的活动和生存是不可缺少的。多种因素使 ER 稳态被打破，发生错误折叠和未折叠蛋白反应（unfolded protein response，UPR），在 ER 腔内聚集以及引起钙离子平衡紊乱，称为内质网应激（endoplasmic reticulum stress，ERS）。葡萄糖调节蛋白 78 （glucose regulated protein 78，GRP78）作为一种分子伴侣，在蛋白质的折叠、转运过程和 ERS 反应中发挥重要作用。近年发现，GRP78在泌尿系肿瘤中过表达，可能与泌尿系肿瘤，如前列腺癌、肾细胞癌、膀胱癌的恶性生物学行为，如增殖、凋亡、侵袭等密切相关[1-2] ，本文对 GRP78表达在泌尿系肿瘤的研究进展作一综述。

1 GRP78 概括

2 GRP78 在肿瘤中的表达及临床意义

3 GRP78 在泌尿系肿瘤中的表达
    3.1 GRP78 在肾癌中的表达
    3.2 GRP78在膀胱癌的表达
    3.3 GRP78 在前列腺癌的表达

4 小结

4 小结

GRP78 在泌尿系肿瘤，如前列腺癌、膀胱癌、肾癌呈高表达，与肿瘤增殖、转移、耐药等恶性生物学行为密切相关，提示其可能是一个良好的生物学标志物和治疗靶点。GRP78联合新型纳米颗粒给药系统的初步成功，也为抗肿瘤治疗提供了新的方向和希望。但目前关于 GRP78在泌尿系肿瘤的相关研究大多数为基础研究，具体作用机制需要进一步探讨，还需要大规模、多中心、随机对照研究证实其临床有效性。相信随着研究的深入，GRP78可能成为泌尿系肿瘤一个有效的治疗靶点和预后标志物。

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