摘要:肾细胞癌 (renal cell carcinoma, RCC) 是泌尿系统常见恶性肿瘤,早期或局限性 RCC可通过手术获得治愈, 对于晚期或转移性 RCC,靶向和免疫检查点抑制剂治疗可提高部分患者总生存率,但总体预后仍不佳。近年发现长链 非编码 RNA (long non-coding RNAs,lncRNAs) 可能成为临床诊断和治疗 RCC新靶标,本文就 lncRNAs在 RCC 中的研究进展作一综述。
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[1] SIEGEL RL, MILLER KD, FUCHS HE, et al. Cancer statistics, 2021 [J]. CA Cancer J Clin, 2021,71(1):7-33
[2] ZHANG J, ZHANG X, PIAO C, et al. A long non-coding rna signature to improve prognostic prediction in clear cell renal cell carcinoma [J]. Biomed Pharmacother, 2019, 118:109079
[3] RINI BI, PAL SK, ESCUDIER BJ, et al. Tivozanib versus sorafenib in patients with advanced renal cell carcinoma (tivo- 3): A phase 3, multicentre, randomised, controlled, open- label study [J]. Lancet Oncol, 2020,21(1): 95-104
[4] GORE ME, JONES RJ, RAVAUD A, et al. Sorafenib dose escalation in treatment- naive patients with metastatic renal cell carcinoma: A non- randomised, open- label, phase 2b study [J]. BJU Int, 2017,119(6):846-853
[5] ARASARATNAR M, GURNEY H. Nivolumab in the treatment of advanced renal cell carcinoma [J]. Fut Oncol, 2018,14(17):1679-1689
[6] ESCUDIER B, MOTZER RJ, SHARMA P, et al. Treatment beyond progression in patients with advanced renal cell carcinoma treated with nivolumab in checkmate 025 [J]. Eur Urol, 2017,72(3):368-376
[7] SLACK FJ, CHINNAIYAN AM. The role of non- coding rnas in oncology [J]. Cell, 2019,179(5):1033-1055
[8] GANDHI M, CAUDRON- HERGER M, DIEDERICHS S. Rna motifs and combinatorial prediction of interactions, stability and localization of noncoding rnas [J]. Nat Struct Mol Biol, 2018,25(12):1070-1076
[9] DERRIEN T, JOHNSON R, BUSSOTTI G, et al. The gencode v7 catalog of human long noncoding rnas: Analysis of their gene structure, evolution, and expression [J]. Genome Res, 2012,22(9):1775-1789
[10] CARNINCI P, KASUKAWA T, KATAYAMA S, et al. The transcriptional landscape of the mammalian genome [J]. Science, 2005,309(5740):1559-1563
[11] MA L, BAJIC VB, ZHANG Z. On the classification of long non-coding rnas [J]. RNA Biol, 2013,10(6):925-933
[12] GUTTMAN M, RINN JL. Modular regulatory principles of large non- coding rnas [J]. Nature, 2012,482(7385):339- 346
[13] BATISTA PJ, CHANG HY. Long noncoding rnas: Cellu-lar address codes in development and disease [J]. Cell, 2013,152(6):1298-1307
[14] THOMSON DW, DINGER ME. Endogenous microrna sponges: evidence and controversy [J]. Nat Rev Genet, 2016,17(5):272-283
[15] SALMENA L, POLISENO L, Tay Y, et al. A cerna hypothesis: The rosetta stone of a hidden rna language? [J]. Cell, 2011,146(3):353-358
[16] TAY Y, RINN J, PANDOLFI PP. The multilayered complexity of cerna crosstalk and competition [J]. Nature, 2014,505(7483):344-352
[17] CHEN S, MA P, ZHAO Y, et al. Biological function and mechanism of malat-1 in renal cell carcinoma proliferation and apoptosis: role of the malat-1-livin protein interaction [J]. J Physiol Sci, 2017,67(5):577-585
[18] LI Z, MA Z, XU X. Long noncoding rna malat1 correlates with cell viability and mobility by targeting mir223p in renal cell carcinoma via the pi3k/akt pathway [J]. Oncol Rep, 2019,41(2):1113-1121
[19] WANG K, JIN W, SONG Y, et al. Lncrna rp11- 436h11.5, functioning as a competitive endogenous rna, upregulates bcl- w expression by sponging mir- 335- 5p and promotes proliferation and invasion in renal cell carcinoma [J]. Mol Cancer, 2017,16(1):166
[20] QI Y, MA Y, PENG Z, et al. Long noncoding rna peng upregulates pdzk1 expression by sponging mir-15b to suppress clear cell renal cell carcinoma cell proliferation [J]. Oncogene, 2020,39(22):4404-4420
[21] REN Y, HUANG W, WENG G, et al. Lncrna pvt1 promotes proliferation, invasion and epithelial- mesenchymal transition of renal cell carcinoma cells through downregulation of mir-16-5p [J]. Onco Targets Ther, 2019,12:2563- 2575
[22] ZHAI W, ZHU R, MA J, et al. A positive feed-forward loop between lncrna- urrcc and egfl7/p- akt/foxo3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma [J]. Mol Cancer, 2019,18(1):81
[23] LI JK, CHEN C, LIU JY, et al. Long noncoding rna mrccat1 promotes metastasis of clear cell renal cell carcinoma via inhibiting npr3 and activating p38- mapk signaling [J]. Mol Cancer, 2017,16(1):111
[24] LIU Y, CHENG G, HUANG Z, et al. Long noncoding rna snhg12 promotes tumour progression and sunitinib resistance by upregulating cdca3 in renal cell carcinoma [J]. Cell Death Dis, 2020,11(7):515
[25] WANG Z, CHANG X, ZHU G, et al. Depletion of lncrna malat1 inhibited sunitinib resistance through regulating mir- 362- 3p- mediated g3bp1 in renal cell carcinoma [J]. Cell Cycle, 2020:1-9
[26] ZHAI W, SUN Y, GUO C, et al. Lncrna- sarcc suppresses renal cell carcinoma (RCC) progression via altering the androgen receptor(ar)/mirna- 143- 3p signals [J]. Cell Death Differ, 2017,24(9):1502-1517
[27] MOTZER RJ, JONASCH E, MICHAELSON MD, et al. Nccn guidelines insights: kidney cancer, version 2.2020 [J]. J Natl Compr Canc Netw, 2019,17(11):1278-1285
[28] HE ZH, QIN XH, ZHANG XL, et al. Long noncoding rna gihcg is a potential diagnostic and prognostic biomarker and therapeutic target for renal cell carcinoma [J]. Eur Rev Med Pharmacol Sci, 2018,22(1):46-54
[29] CHEN J, CHEN Y, GU L, et al. Lncrnas act as prognostic and diagnostic biomarkers in renal cell carcinoma: A systematic review and meta-analysis [J]. Oncotarget, 2016, 7(45):74325-74336
[30] SHI J, ZHANG W, TIAN H, et al. Lncrna ror promotes the proliferation of renal cancer and is negatively associated with favorable prognosis [J]. Mol Med Rep, 2017, 16(6):9561-9566
[31] XING Q, LI R, XU A, et al. Genetic variants in a long noncoding rna related to sunitinib resistance predict risk and survival of patients with renal cell carcinoma [J]. Cancer Med, 2019,8(6):2886-2896
[32] HE W, ZHONG G, WANG P, et al. Downregulation of long noncoding rna fendrr predicts poor prognosis in renal cell carcinoma [J]. Oncol Lett, 2019,17(1):103-112.
郑盛锋,吴潇芸,付伟金. 长链非编码RNA在肾细胞癌中的研究进展[J]. 泌尿外科杂志(电子版),2021,13(3):94-97. DOI:10.3969/j.issn.1674-7410.2021.03.023.
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肾细胞癌 (renal cell carcinoma,RCC) 是泌 尿系统常见的恶性肿瘤,占恶性肿瘤的3%。2021年, 美国预计 RCC新发病患者 76 080例,预计病死患者 13 780 例[1] 。早期或局限性 RCC 可通过根治性肾切 除术治愈,但约 1/3的患者在就诊时已进入晚期或发 生转移[2] 。由于晚期 RCC对放化疗均不敏感,靶向治 疗如索拉非尼等[3-4] ,或免疫治疗如纳武单抗等[5-6] 成 为主要治疗手段,虽然提高了部分患者总生存率 (overall survival,OS) 和无进展生存期 (progress free survival,PFS),但容易产生耐药,副作用大, 限制了其在临床中的应用。近年发现,长链非编码 RNA (long non- coding RNAs, lncRNAs) 在 RCC 的发生发展过程中发挥重要调控作用,可能成 为临床诊断和治疗 RCC新靶标,本文就 lncRNAs在 RCC中的研究进展作一综述。
1 lncRNAs 概述
2 lncRNAs 在 RCC 中的作用
2.1 lncRNAs在 RCC细胞功能中的作用
2.1.1 lncRNAs 调控 RCC 细胞增殖
2.1.2 lncRNAs 促进 RCC 细胞转移
2.1.3 lncRNAs与 RCC耐药
2.2 lncRNAs作为 RCC的生物分子标志物
2.2.1 lncRNAs作为 RCC的诊断分子标志物
2.2.2 lncRNAs 作为评估 RCC 预后的分子标志物
3 小结与展望
3 小结与展望
lncRNAs在 RCC 的发生发展过程中可能发挥复 杂的调控作用,阐明 lncRNAs的分子调控机制,对 明确 RCC 发生发展的机制,以及开发新的诊断和治 疗靶标具有重要意义。相关研究证实,lncRNAs 介 导 miRNA 靶向调控目的基因表达,是其调控 RCC 的重要分子机制,可作为一个重要的研究方向。目 前对 lncRNAs的研究尚处于起步阶段,且大多数为 基础研究,要将 lncRNAs应用于 RCC临床诊断和治 疗,仍需更大规模的实验研究和临床试验。
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