收稿日期：2023-02-10 接受日期：2023-02-10 出版日期：2023-02-10 发布日期：2023-02-10
通讯作者： 李文智,副主任医师,上海交通大学医学院附属第九人民医院 泌尿外科，上海
作者简介： 韦自卫,上海交通大学医学院附属第九人民医院 泌尿外科，上海 . 王忠,上海交通大学医学院附属第九人民医院 泌尿外科，上海 . 李文智,男,上海交通大学医学院附属第九人民医院 泌尿外科，上海,副主任医师,泌尿肿瘤亚学科带组组长、负责人，全国十大医学新锐。美国USC和CCF高级访问学者。医疗专长为泌尿系肿瘤临床及基础研究和微创机器人技术的改良与应用，前列腺癌的早期诊断和综合治疗，泌尿系结石和前列腺增生的腔内手术治疗，男性病的规范化诊治。 .
基金资助：上海市自然科学基金面上项目 （20ZR1431400），项目负责人： 李文智
中图分类号：R737.1
文献标识码：A
文章编号：1674-7410(2022)02-0069-05
DOI：10.20020/j.CNKI.1674-7410.2022.02.12
关键词：
摘要：高尔基磷酸化蛋白3（golgi phosphoprotein 3，GOLPH3） 具有典型的高尔基体结构，发挥着维持高尔基体正常形态结构和生理功能的重要作用。在多种肿瘤的研究中，GOLPH3均被证明呈高表达状态，与肿瘤的发生和转移密切相关。近年来随着研究的不断深入，成为肿瘤诊治的重要靶点，因此文章对高尔基磷酸化蛋白 3在肿瘤中的研究进展进行综述。
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[1]韦自卫,王忠,李文智.高尔基磷酸化蛋白3在肿瘤中的研究进展[J].泌尿外科杂志(电子版),2022,14(02):69-73.DOI:10.20020/j.CNKI.1674-7410.2022.02.12.
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高尔基体在细胞生长和促进癌基因转化方面发挥重要作用[1]。高尔基磷酸化蛋白 3 （golgi phosphoprotein 3，GOLPH3） 定位于高尔基体，参与高尔基体带状结构的维持、囊泡转运和糖基化等。作为人类癌症的新型蛋白，GOLPH3是第一个在高尔基体发现的癌基因[2]。GOLPH3可能通过多种细胞活动参与肿瘤的发生发展，包括调节高尔基体的质膜转运、影响 DNA 损伤反应和维持遗传物质稳定性、介导癌相关蛋白的糖基化或控制关键信号分子的内吞再循环等。随着细胞器在肿瘤研究中的日益深入，GOLPH3作为肿瘤标志物的价值越来越被研究者重视。在泌尿系统肿瘤中，GOLPH3也发挥重要作用。本文综述了 GOLPH3的结构和功能特点、在肿瘤中的表达以及在肿瘤中的可能作用机制。
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