收稿日期：2023-02-13 接受日期：2023-02-13 出版日期：2023-02-13 发布日期：2023-02-13
通讯作者： 李笑然,兰州大学第二医院 泌尿外科，甘肃 兰州 730000
作者简介： 冯德梅,兰州大学第二临床医学院 泌尿外科，甘肃 兰州 . 胡琴琴,兰州大学第二临床医学院 泌尿外科，甘肃 兰州 . 南晓娟,兰州大学第二临床医学院 泌尿外科，甘肃 兰州 . 范菊雅,兰州大学第二临床医学院 泌尿外科，甘肃 兰州 . 王朝名,兰州大学第二临床医学院 泌尿外科，甘肃 兰州 . 李笑然,兰州大学第二医院 泌尿外科，甘肃 兰州 730000 .
基金资助：国家自然科学基金资助（81700614）；兰州大学第二医院“萃英学子科研培育”计划（Cuiying ScientificTrainingProgramforUndergradu- atesofLanzhouUniversitySecondHospital），项目负责人： 李笑然
中图分类号：R691.4
文献标识码：A
文章编号：
DOI：10.3969/j.issn.1674-7410.2021.01.001
关键词：
泌尿系结石作为一种全球性疾病，其发病由性别、年龄、遗传因素、环境因素、饮食习惯等多种因素共同导致，其发病率和复发率呈上升趋势，因此引起全球广泛关注。近年来，结石患者的内科和外科治疗取得了重大进展，但主要是以外科治疗为主，尤其微创取石技术使大部分结石患者获益，但是成本昂贵，不适用于所有患者[1,2]。钙敏感受体（calcium- sensing receptor, CaSR） 自发现以来就被广泛关注，一项系统综述表明 CaSR基因不同部位的多态性可能与钙结石的形成有关[3]。但是尚有部分机制未阐明，也缺乏系统的阐述。本文就 CaSR的结构及其对血清钙浓度的调节和 CaSR的信号转导及其基因多态性等方面与钙性泌尿系结石发生的关系做一综述，旨在为泌尿系结石发现潜在的治疗和预防药物。
图1 CaSR 对 Ca2+的调节示意图
图2 CaSR 信号转导示意图
图3 Claudin-14 信号通路示意图
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3 CaSR 基因多态性与泌尿系结石
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